@ Colts
3-3
@ 49ers
3-3
Playoffs
0-0
VS EXPECTED
Colts +0.5
Avg Points
23.8-24.4
Most Recent Winner
49ers 27-48
Head-To-Head Margin (Max Last 150 Matches)
| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Dec 22, 2025 | 48–27 | San Francisco 49ers +21 | San Francisco 49ers +0.2 | Regular | |
| Oct 24, 2021 | 30–18 | Indianapolis Colts +12 | San Francisco 49ers +2.0 | Regular | |
| Oct 8, 2017 | 23–26 | Indianapolis Colts +3 | Indianapolis Colts +8.2 | Regular | |
| Sep 22, 2013 | 27–7 | Indianapolis Colts +20 | San Francisco 49ers +8.1 | Regular | |
| Nov 1, 2009 | 14–18 | Indianapolis Colts +4 | Indianapolis Colts +13.8 | Regular | |
| Oct 9, 2005 | 28–3 | Indianapolis Colts +25 | Indianapolis Colts +8.1 | Regular | |
| Nov 25, 2001 | 40–21 | San Francisco 49ers +19 | Indianapolis Colts +3.8 | Regular | |
| Oct 18, 1998 | 31–34 | San Francisco 49ers +3 | San Francisco 49ers +15.5 | Regular | |
| Oct 15, 1995 | 17–18 | Indianapolis Colts +1 | San Francisco 49ers +7.4 | Regular | |
| Sep 10, 1989 | 30–24 | San Francisco 49ers +6 | San Francisco 49ers +2.3 | Regular | |
| Oct 5, 1986 | 14–35 | San Francisco 49ers +21 | San Francisco 49ers +16.5 | Regular | |
| Nov 12, 1972 | 21–24 | San Francisco 49ers +3 | San Francisco 49ers +4.3 | Regular |