Final Score: 49ers 48 - Colts 27
Monday, December 22, 2025 at 8:15 PM ET
49ers @ Colts
NFL model probabilities, projected margin and matchup analysis
Model Prediction Through Season
| Stat | 49ers | Colts |
|---|---|---|
| All-time wins | 5 | 6 |
| Last 5 meetings | 0 | 5 |
| Average points | 22.3 | 23.5 |
| Last meeting | 18 | 30 |
| Stat | 49ers | Colts |
|---|---|---|
| Games played | 14 | 14 |
| Avg points scored | 24.6 | 28.0 |
| Avg points conceded | 20.9 | 21.6 |
| Win percentage | 71% | 57% |
| Away win % / Home win % | 75% | 86% |
Recent Results
49ers
vs Tennessee Titans
Dec 14, 2025 · Margin: +13 · Total: 61
37-24
@ Cleveland Browns
Nov 30, 2025 · Margin: +18 · Total: 34
26-8
vs Carolina Panthers
Nov 24, 2025 · Margin: +11 · Total: 29
20-9
@ Arizona Cardinals
Nov 16, 2025 · Margin: +19 · Total: 63
41-22
vs Los Angeles Rams
Nov 9, 2025 · Margin: -16 · Total: 68
26-42
@ New York Giants
Nov 2, 2025 · Margin: +10 · Total: 58
34-24
@ Houston Texans
Oct 26, 2025 · Margin: -11 · Total: 41
15-26
vs Atlanta Falcons
Oct 19, 2025 · Margin: +10 · Total: 30
20-10
@ Tampa Bay Buccaneers
Oct 12, 2025 · Margin: -11 · Total: 49
19-30
@ Los Angeles Rams
Oct 2, 2025 · Margin: +3 · Total: 49
26-23
Colts
@ Seattle Seahawks
Dec 14, 2025 · Margin: -2 · Total: 34
16-18
@ Jacksonville Jaguars
Dec 7, 2025 · Margin: -17 · Total: 55
19-36
vs Houston Texans
Nov 30, 2025 · Margin: -4 · Total: 36
16-20
@ Kansas City Chiefs
Nov 23, 2025 · Margin: -3 · Total: 43
20-23
vs Atlanta Falcons
Nov 9, 2025 · Margin: +6 · Total: 56
31-25
@ Pittsburgh Steelers
Nov 2, 2025 · Margin: -7 · Total: 47
20-27
vs Tennessee Titans
Oct 26, 2025 · Margin: +24 · Total: 52
38-14
@ Los Angeles Chargers
Oct 19, 2025 · Margin: +14 · Total: 62
38-24
vs Arizona Cardinals
Oct 12, 2025 · Margin: +4 · Total: 58
31-27
vs Las Vegas Raiders
Oct 5, 2025 · Margin: +34 · Total: 46
40-6