@ Panthers
6-6
@ 49ers
7-5
Playoffs
0-1
VS EXPECTED
Panthers +3.0
Avg Points
23.5-23.2
Most Recent Winner
49ers 9-20
Head-To-Head Margin (Max Last 150 Matches)
| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Nov 24, 2025 | 9–20 | San Francisco 49ers +11 | San Francisco 49ers +8.6 | Regular | |
| Oct 9, 2022 | 37–15 | San Francisco 49ers +22 | San Francisco 49ers +4.8 | Regular | |
| Oct 27, 2019 | 13–51 | San Francisco 49ers +38 | San Francisco 49ers +2.7 | Regular | |
| Sep 10, 2017 | 23–3 | Carolina Panthers +20 | Carolina Panthers +4.6 | Regular | |
| Sep 18, 2016 | 27–46 | Carolina Panthers +19 | Carolina Panthers +9.9 | Regular | |
| Jan 12, 2014 | 23–10 | San Francisco 49ers +13 | San Francisco 49ers +0.3 | Playoffs | |
| Nov 10, 2013 | 10–9 | Carolina Panthers +1 | San Francisco 49ers +5.4 | Regular | |
| Oct 24, 2010 | 20–23 | Carolina Panthers +3 | Carolina Panthers +4.2 | Regular | |
| Dec 2, 2007 | 14–31 | Carolina Panthers +17 | Carolina Panthers +6.4 | Regular | |
| Nov 14, 2004 | 37–27 | Carolina Panthers +10 | San Francisco 49ers +2.0 | Regular | |
| Nov 18, 2001 | 25–22 | San Francisco 49ers +3 | San Francisco 49ers +0.3 | Regular | |
| Oct 7, 2001 | 14–24 | San Francisco 49ers +10 | San Francisco 49ers +2.7 | Regular | |
| Oct 22, 2000 | 16–34 | Carolina Panthers +18 | Carolina Panthers +5.0 | Regular | |
| Sep 10, 2000 | 38–22 | Carolina Panthers +16 | San Francisco 49ers +1.5 | Regular | |
| Dec 18, 1999 | 24–41 | Carolina Panthers +17 | Carolina Panthers +3.0 | Regular | |
| Oct 17, 1999 | 31–29 | Carolina Panthers +2 | San Francisco 49ers +9.6 | Regular | |
| Dec 6, 1998 | 31–28 | San Francisco 49ers +3 | San Francisco 49ers +6.6 | Regular | |
| Nov 8, 1998 | 23–25 | San Francisco 49ers +2 | San Francisco 49ers +12.3 | Regular | |
| Nov 16, 1997 | 19–27 | San Francisco 49ers +8 | San Francisco 49ers +9.3 | Regular | |
| Sep 29, 1997 | 34–21 | San Francisco 49ers +13 | San Francisco 49ers +0.3 | Regular | |
| Dec 8, 1996 | 30–24 | Carolina Panthers +6 | San Francisco 49ers +7.8 | Regular | |
| Sep 22, 1996 | 7–23 | Carolina Panthers +16 | San Francisco 49ers +4.1 | Regular | |
| Dec 10, 1995 | 31–10 | San Francisco 49ers +21 | San Francisco 49ers +7.4 | Regular | |
| Nov 5, 1995 | 13–7 | Carolina Panthers +6 | San Francisco 49ers +12.6 | Regular |