| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Oct 24, 2021 | 30–18 | Colts +12 | 49ers +2.0 | Regular Season | |
| Oct 24, 2021 | 5–31 | Cardinals +26 | Cardinals +12.0 | Regular Season | |
| Oct 24, 2021 | 3–38 | Buccaneers +35 | Buccaneers +10.1 | Regular Season | |
| Oct 24, 2021 | 19–28 | Rams +9 | Rams +16.4 | Regular Season | |
| Oct 24, 2021 | 22–33 | Raiders +11 | Raiders +5.0 | Regular Season | |
| Oct 24, 2021 | 30–28 | Falcons +2 | Dolphins +2.7 | Regular Season | |
| Oct 24, 2021 | 41–17 | Bengals +24 | Ravens +10.9 | Regular Season | |
| Oct 24, 2021 | 3–25 | Giants +22 | Panthers +0.3 | Regular Season | |
| Oct 24, 2021 | 10–24 | Packers +14 | Packers +13.3 | Regular Season | |
| Oct 24, 2021 | 3–27 | Titans +24 | Chiefs +0.3 | Regular Season | |
| Oct 24, 2021 | 13–54 | Patriots +41 | Patriots +9.9 | Regular Season |