| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Sep 19, 2021 | 35–36 | Ravens +1 | Chiefs +0.3 | Regular Season | |
| Sep 19, 2021 | 20–17 | Cowboys +3 | Chargers +5.1 | Regular Season | |
| Sep 19, 2021 | 33–30 | Titans +3 | Seahawks +5.3 | Regular Season | |
| Sep 19, 2021 | 33–34 | Cardinals +1 | Cardinals +4.5 | Regular Season | |
| Sep 19, 2021 | 25–48 | Buccaneers +23 | Buccaneers +11.2 | Regular Season | |
| Sep 19, 2021 | 35–0 | Bills +35 | Bills +0.5 | Regular Season | |
| Sep 19, 2021 | 7–26 | Panthers +19 | Saints +6.4 | Regular Season | |
| Sep 19, 2021 | 17–20 | Bears +3 | Bears +5.7 | Regular Season | |
| Sep 19, 2021 | 21–31 | Browns +10 | Browns +5.4 | Regular Season | |
| Sep 19, 2021 | 23–13 | Broncos +10 | Broncos +2.8 | Regular Season | |
| Sep 19, 2021 | 27–24 | Rams +3 | Colts +0.5 | Regular Season | |
| Sep 19, 2021 | 26–17 | Raiders +9 | Steelers +6.1 | Regular Season | |
| Sep 19, 2021 | 25–6 | Patriots +19 | Patriots +4.4 | Regular Season | |
| Sep 19, 2021 | 17–11 | 49ers +6 | Eagles +2.0 | Regular Season |