| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Sep 12, 2021 | 14–34 | Rams +20 | Rams +5.5 | Regular Season | |
| Sep 12, 2021 | 29–33 | Chiefs +4 | Chiefs +8.9 | Regular Season | |
| Sep 12, 2021 | 27–13 | Broncos +14 | Giants +2.1 | Regular Season | |
| Sep 12, 2021 | 3–38 | Saints +35 | Saints +2.7 | Regular Season | |
| Sep 12, 2021 | 17–16 | Dolphins +1 | Patriots +2.7 | Regular Season | |
| Sep 12, 2021 | 38–13 | Cardinals +25 | Titans +6.3 | Regular Season | |
| Sep 12, 2021 | 32–6 | Eagles +26 | Falcons +5.3 | Regular Season | |
| Sep 12, 2021 | 23–16 | Steelers +7 | Bills +7.0 | Regular Season | |
| Sep 12, 2021 | 14–19 | Panthers +5 | Panthers +5.0 | Regular Season | |
| Sep 12, 2021 | 24–27 | Bengals +3 | Vikings +2.3 | Regular Season | |
| Sep 12, 2021 | 41–33 | 49ers +8 | 49ers +2.4 | Regular Season | |
| Sep 12, 2021 | 21–37 | Texans +16 | Texans +7.7 | Regular Season | |
| Sep 12, 2021 | 28–16 | Seahawks +12 | Colts +2.6 | Regular Season | |
| Sep 12, 2021 | 20–16 | Chargers +4 | Commanders +2.0 | Regular Season |