| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Nov 21, 2010 | 17–27 | Eagles +10 | Eagles +4.9 | Regular Season | |
| Nov 21, 2010 | 28–31 | Patriots +3 | Patriots +2.7 | Regular Season | |
| Nov 21, 2010 | 34–17 | Falcons +17 | Falcons +7.4 | Regular Season | |
| Nov 21, 2010 | 19–34 | Saints +15 | Saints +11.3 | Regular Season | |
| Nov 21, 2010 | 21–0 | Buccaneers +21 | 49ers +2.5 | Regular Season | |
| Nov 21, 2010 | 31–3 | Packers +28 | Packers +0.7 | Regular Season | |
| Nov 21, 2010 | 37–13 | Ravens +24 | Ravens +5.7 | Regular Season | |
| Nov 21, 2010 | 13–31 | Chiefs +18 | Chiefs +2.2 | Regular Season | |
| Nov 21, 2010 | 20–24 | Jaguars +4 | Jaguars +4.6 | Regular Season | |
| Nov 21, 2010 | 27–30 | Jets +3 | Jets +9.3 | Regular Season | |
| Nov 21, 2010 | 19–16 | Commanders +3 | Titans +9.4 | Regular Season | |
| Nov 21, 2010 | 49–31 | Bills +18 | Bengals +5.1 | Regular Season | |
| Nov 21, 2010 | 19–35 | Cowboys +16 | Cowboys +10.7 | Regular Season | |
| Nov 21, 2010 | 3–35 | Steelers +32 | Steelers +9.6 | Regular Season |