| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Oct 10, 2010 | 27–24 | Eagles +3 | Eagles +3.6 | Regular Season | |
| Oct 10, 2010 | 34–27 | Titans +7 | Cowboys +3.6 | Regular Season | |
| Oct 10, 2010 | 27–35 | Raiders +8 | Chargers +7.4 | Regular Season | |
| Oct 10, 2010 | 20–30 | Cardinals +10 | Saints +3.3 | Regular Season | |
| Oct 10, 2010 | 20–10 | Falcons +10 | Falcons +4.4 | Regular Season | |
| Oct 10, 2010 | 23–6 | Bears +17 | Panthers +2.5 | Regular Season | |
| Oct 10, 2010 | 24–21 | Buccaneers +3 | Bengals +5.1 | Regular Season | |
| Oct 10, 2010 | 34–10 | Giants +24 | Texans +4.4 | Regular Season | |
| Oct 10, 2010 | 9–19 | Colts +10 | Colts +10.6 | Regular Season | |
| Oct 10, 2010 | 17–31 | Ravens +14 | Ravens +8.0 | Regular Season | |
| Oct 10, 2010 | 36–26 | Jaguars +10 | Bills +2.2 | Regular Season | |
| Oct 10, 2010 | 13–16 | Commanders +3 | Packers +4.4 | Regular Season | |
| Oct 10, 2010 | 6–44 | Lions +38 | Rams +0.2 | Regular Season |