| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Oct 3, 2010 | 3–17 | Giants +14 | Giants +2.3 | Regular Season | |
| Oct 3, 2010 | 10–41 | Chargers +31 | Chargers +5.2 | Regular Season | |
| Oct 3, 2010 | 17–12 | Commanders +5 | Eagles +10.1 | Regular Season | |
| Oct 3, 2010 | 31–24 | Texans +7 | Texans +4.5 | Regular Season | |
| Oct 3, 2010 | 28–31 | Jaguars +3 | Colts +6.4 | Regular Season | |
| Oct 3, 2010 | 14–16 | Falcons +2 | Falcons +8.6 | Regular Season | |
| Oct 3, 2010 | 14–16 | Saints +2 | Saints +9.9 | Regular Season | |
| Oct 3, 2010 | 17–14 | Ravens +3 | Steelers +5.5 | Regular Season | |
| Oct 3, 2010 | 38–14 | Jets +24 | Jets +4.1 | Regular Season | |
| Oct 3, 2010 | 20–23 | Browns +3 | Bengals +2.3 | Regular Season | |
| Oct 3, 2010 | 26–20 | Broncos +6 | Titans +7.6 | Regular Season | |
| Oct 3, 2010 | 26–28 | Packers +2 | Packers +16.6 | Regular Season | |
| Oct 3, 2010 | 3–20 | Rams +17 | Seahawks +2.4 | Regular Season |