| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Sep 26, 2010 | 31–23 | Jets +8 | Jets +0.3 | Regular Season | |
| Sep 26, 2010 | 27–13 | Colts +14 | Colts +4.4 | Regular Season | |
| Sep 26, 2010 | 20–27 | Seahawks +7 | Chargers +5.3 | Regular Season | |
| Sep 26, 2010 | 23–24 | Cardinals +1 | Cardinals +9.6 | Regular Season | |
| Sep 26, 2010 | 28–3 | Eagles +25 | Eagles +2.3 | Regular Season | |
| Sep 26, 2010 | 16–30 | Rams +14 | Commanders +4.4 | Regular Season | |
| Sep 26, 2010 | 10–24 | Vikings +14 | Vikings +14.5 | Regular Season | |
| Sep 26, 2010 | 10–31 | Chiefs +21 | Chiefs +2.1 | Regular Season | |
| Sep 26, 2010 | 27–24 | Falcons +3 | Saints +7.9 | Regular Season | |
| Sep 26, 2010 | 38–13 | Steelers +25 | Steelers +4.4 | Regular Season | |
| Sep 26, 2010 | 17–24 | Ravens +7 | Ravens +10.1 | Regular Season | |
| Sep 26, 2010 | 30–38 | Patriots +8 | Patriots +9.1 | Regular Season | |
| Sep 26, 2010 | 20–7 | Bengals +13 | Panthers +3.6 | Regular Season | |
| Sep 26, 2010 | 27–13 | Cowboys +14 | Texans +4.6 | Regular Season | |
| Sep 26, 2010 | 29–10 | Titans +19 | Giants +2.7 | Regular Season |