@ Panthers
1-3
@ Bills
1-4
Playoffs
0-0
VS EXPECTED
Panthers -2.2
Avg Points
13.8-23.7
Most Recent Winner
Bills 9-40
Head-To-Head Margin (Max Last 150 Matches)
| Date | Matchup | Result | Winner | Model Projection | Stage |
|---|---|---|---|---|---|
| Oct 26, 2025 | 40–9 | Buffalo Bills +31 | Buffalo Bills +6.8 | Regular | |
| Dec 19, 2021 | 14–31 | Buffalo Bills +17 | Buffalo Bills +12.1 | Regular | |
| Sep 17, 2017 | 3–9 | Carolina Panthers +6 | Carolina Panthers +5.7 | Regular | |
| Sep 15, 2013 | 23–24 | Buffalo Bills +1 | Buffalo Bills +1.9 | Regular | |
| Oct 25, 2009 | 20–9 | Buffalo Bills +11 | Carolina Panthers +5.0 | Regular | |
| Nov 27, 2005 | 13–9 | Carolina Panthers +4 | Carolina Panthers +0.3 | Regular | |
| Dec 9, 2001 | 24–25 | Buffalo Bills +1 | Buffalo Bills +2.7 | Regular | |
| Oct 25, 1998 | 30–14 | Buffalo Bills +16 | Carolina Panthers +2.0 | Regular | |
| Sep 10, 1995 | 9–31 | Buffalo Bills +22 | Buffalo Bills +2.7 | Regular |