Records since the 1969 season.
| Matchup | Record | Win % | Vs Expected | Games |
|---|---|---|---|---|
| Mariners Rangers | 393-378-3 | 51.0% | +14.3 | 751 |
| Mariners Angels | 354-406-7 | 46.6% | -14.3 | 748 |
| Mariners Athletics | 363-391-7 | 48.1% | -1.4 | 741 |
| Mariners Twins | 253-241-1 | 51.2% | +9.7 | 486 |
| Mariners Royals | 242-250 | 49.2% | +1.8 | 479 |
| Mariners White Sox | 235-255 | 48.0% | -1.5 | 478 |
| Mariners Yankees | 201-277-3 | 42.1% | -3.6 | 473 |
| Mariners Red Sox | 197-268-3 | 42.4% | -10.6 | 460 |
| Mariners Orioles | 217-250 | 46.5% | -8.5 | 454 |
| Mariners Guardians | 210-254 | 45.3% | -13.2 | 453 |
| Mariners Tigers | 219-238-4 | 47.9% | -7.3 | 448 |
| Mariners Blue Jays | 216-233-3 | 48.1% | -0.6 | 444 |
| Mariners Brewers | 121-130-3 | 48.2% | +4.9 | 249 |
| Mariners Astros | 104-136-5 | 43.3% | -13.3 | 233 |
| Mariners Rays | 119-97-3 | 55.1% | +6.7 | 214 |
| Mariners Padres | 73-70 | 51.0% | -0.7 | 137 |
| Mariners Rockies | 34-26-3 | 56.7% | -0.9 | 59 |
| Mariners Giants | 26-26 | 50.0% | -0.4 | 50 |
| Mariners Dodgers | 17-34 | 33.3% | -5.9 | 49 |
| Mariners Diamondbacks | 29-19 | 60.4% | +4.1 | 46 |
| Mariners Nationals | 13-24 | 35.1% | -7.5 | 34 |
| Mariners Phillies | 14-14-3 | 50.0% | -1.7 | 29 |
| Mariners Braves | 18-13 | 58.1% | +3.2 | 29 |
| Mariners Cubs | 10-18-3 | 35.7% | -6.1 | 29 |
| Mariners Cardinals | 17-13 | 56.7% | +2.4 | 28 |
| Mariners Marlins | 13-17 | 43.3% | -2.8 | 28 |
| Mariners Reds | 22-8 | 73.3% | +5.8 | 28 |
| Mariners Pirates | 18-11 | 62.1% | +2.5 | 27 |
| Mariners Mets | 19-11 | 63.3% | +3.2 | 27 |
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