Records since the 1969 season.
| Matchup | Record | Win % | Vs Expected | Games |
|---|---|---|---|---|
| Red Sox Yankees | 446-473-8 | 48.5% | +0.3 | 886 |
| Red Sox Orioles | 489-396-7 | 55.3% | +14.0 | 839 |
| Red Sox Blue Jays | 403-341-10 | 54.2% | -1.1 | 728 |
| Red Sox Guardians | 347-295-3 | 54.0% | -2.2 | 601 |
| Red Sox Tigers | 350-270 | 56.5% | +14.3 | 594 |
| Red Sox Athletics | 318-257-7 | 55.3% | +14.9 | 567 |
| Red Sox Angels | 310-258-6 | 54.6% | +4.9 | 560 |
| Red Sox Rangers | 294-268-6 | 52.3% | -15.2 | 547 |
| Red Sox White Sox | 278-252-7 | 52.5% | -13.6 | 513 |
| Red Sox Twins | 279-246 | 53.1% | -5.5 | 504 |
| Red Sox Royals | 269-249-3 | 51.9% | -15.4 | 496 |
| Red Sox Rays | 267-233-7 | 53.4% | -9.7 | 486 |
| Red Sox Mariners | 266-196-6 | 57.6% | +5.8 | 460 |
| Red Sox Brewers | 225-199 | 53.1% | -5.2 | 393 |
| Red Sox Astros | 54-55 | 49.5% | -1.6 | 104 |
| Red Sox Braves | 55-51 | 51.9% | +2.9 | 100 |
| Red Sox Phillies | 54-39 | 58.1% | +4.0 | 90 |
| Red Sox Marlins | 36-17-3 | 67.9% | +3.8 | 54 |
| Red Sox Mets | 28-23-3 | 54.9% | +0.3 | 52 |
| Red Sox Nationals | 29-16-3 | 64.4% | +1.8 | 46 |
| Red Sox Cardinals | 24-17 | 58.5% | +3.2 | 38 |
| Red Sox Rockies | 22-14-3 | 61.1% | -1.2 | 37 |
| Red Sox Reds | 23-13 | 63.9% | +3.7 | 34 |
| Red Sox Dodgers | 16-16-3 | 50.0% | -0.7 | 33 |
| Red Sox Diamondbacks | 16-14-3 | 53.3% | -2.4 | 31 |
| Red Sox Padres | 19-14 | 57.6% | +0.9 | 31 |
| Red Sox Giants | 16-12-3 | 57.1% | -0.3 | 29 |
| Red Sox Cubs | 13-14-3 | 48.1% | -3.2 | 28 |
| Red Sox Pirates | 14-13-3 | 51.9% | -3.0 | 27 |
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